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Judy L Bolton Selected Research

LY 353381 (LY353381)

1/2009Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.
9/2007Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
6/2006Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
2/2005Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.

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Judy L Bolton Research Topics

Disease

32Breast Neoplasms (Breast Cancer)
01/2018 - 04/2002
26Carcinogenesis
11/2020 - 08/2002
23Neoplasms (Cancer)
11/2017 - 04/2002
9Endometrial Neoplasms (Endometrial Cancer)
01/2013 - 06/2003
5Osteoporosis
10/2016 - 08/2002
4Hot Flashes
10/2016 - 09/2003
3Postmenopausal Osteoporosis
05/2014 - 10/2003
2Body Weight (Weight, Body)
11/2017 - 10/2017
2Stroke (Strokes)
02/2005 - 08/2002
2Alzheimer Disease (Alzheimer's Disease)
02/2005 - 08/2002
1Cognitive Dysfunction
10/2016
1Chronic Disease (Chronic Diseases)
10/2016
1Heart Diseases (Heart Disease)
10/2016
1Atrophy
10/2016
1Hepatocellular Carcinoma (Hepatoma)
11/2015
1Leiomyoma (Uterine Fibroids)
03/2012
1Myoma
03/2012
1Lung Neoplasms (Lung Cancer)
01/2010
1Mental Disorders (Mental Disorder)
04/2005
1Coronary Disease (Coronary Heart Disease)
08/2002

Drug/Important Bio-Agent (IBA)

36Estrogens (Estrogen)FDA Link
11/2020 - 04/2002
16Hormones (Hormone)IBA
10/2016 - 08/2002
13Selective Estrogen Receptor Modulators (SERM)IBA
05/2014 - 10/2003
11Estrogen ReceptorsIBA
05/2014 - 04/2002
10QuinonesIBA
11/2020 - 06/2003
9quinone (benzoquinone)IBA
08/2015 - 08/2005
7catechol (pyrocatechol)IBA
08/2015 - 07/2002
6Raloxifene Hydrochloride (Evista)FDA Link
05/2014 - 07/2004
5CatecholsIBA
11/2017 - 06/2003
5Catechol EstrogensIBA
01/2011 - 07/2002
4LuciferasesIBA
01/2018 - 07/2003
4DNA (Deoxyribonucleic Acid)IBA
08/2015 - 03/2009
4NAD (NADH)IBA
06/2012 - 08/2005
4LY 353381 (LY353381)IBA
01/2009 - 02/2005
4TamoxifenFDA LinkGeneric
11/2007 - 07/2003
3Biomarkers (Surrogate Marker)IBA
12/2018 - 06/2009
3Alkaline PhosphataseIBA
01/2018 - 03/2006
3Estradiol (Delestrogen)FDA LinkGeneric
08/2015 - 10/2007
3Oxidoreductases (Dehydrogenase)IBA
06/2012 - 08/2005
3benzothiopheneIBA
01/2009 - 06/2006
2ElementsIBA
01/2018 - 01/2013
2desmethylarzoxifeneIBA
05/2014 - 09/2007
2Reactive Oxygen Species (Oxygen Radicals)IBA
06/2012 - 12/2011
2Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
06/2012 - 05/2003
24-hydroxy-equileninIBA
10/2007 - 12/2004
2AntioxidantsIBA
03/2006 - 11/2002
2EnzymesIBA
08/2005 - 07/2002
2Estrogen Receptor Modulators (Antiestrogen)IBA
07/2003 - 08/2002
2Estrogen Receptor alphaIBA
07/2003 - 04/2002
1Cytochrome P-450 CYP1A1 (CYP1A1)IBA
12/2018
1IsoflavonesIBA
11/2017
18-prenylnaringeninIBA
11/2017
1salicylhydroxamic acid (SHAM)IBA
11/2017
1flavanoneIBA
11/2017
1Phytoestrogens (Phytoestrogen)IBA
10/2017
1EstroneFDA Link
08/2015
1bazedoxifeneIBA
05/2014
1afimoxifene (hydroxytamoxifen)IBA
05/2014
1Antidepressive Agents (Antidepressants)IBA
05/2013
1Messenger RNA (mRNA)IBA
01/2013
1LasofoxifeneIBA
07/2012
1Aromatase (CYP19)IBA
06/2012
1LY2066948IBA
03/2012
1NaphtholsIBA
03/2012
1EquileninIBA
03/2012
1Proteins (Proteins, Gene)FDA Link
01/2012
18-Hydroxy-2'-DeoxyguanosineIBA
12/2011
1CarcinogensIBA
08/2010
1Sulfhydryl Compounds (Thiols)IBA
08/2010
1DNA AdductsIBA
06/2009
1quinone methideIBA
11/2007
14-methoxyequileninIBA
10/2007
11,1'- (4,4,7,7- tetramethyl- 4,7- diazaundecamethylene)bis- 4- (3- methyl- 2,3- dihydro(benzo- 1,3- thiazole)- 2- methylidene)quinolinium (TOTO)IBA
10/2007
1LigandsIBA
10/2007
1Free RadicalsIBA
03/2006
1Complex MixturesIBA
10/2005
1Biological ProductsIBA
10/2005
1NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA
08/2005
1ritetroniumIBA
02/2005
1Conjugated (USP) Estrogens (Premarin)FDA Link
12/2004
1Serotonin (5 Hydroxytryptamine)IBA
09/2003
1Serotonin ReceptorsIBA
09/2003
1Estrogen Receptor betaIBA
07/2003
1Vitamin K 3 (Menadione)FDA Link
11/2002
1ferulic acid (sodium ferulate)IBA
11/2002
1cimiracemate AIBA
11/2002
1caffeic acidIBA
11/2002
1methyl caffeateIBA
11/2002
1cimiracemate BIBA
11/2002
1fukinolic acidIBA
11/2002
1Glutathione Transferase (Glutathione S-Transferase)IBA
07/2002
1CatalaseIBA
07/2002

Therapy/Procedure

10Chemoprevention
12/2018 - 07/2003
9Therapeutics
01/2018 - 10/2003
8Hormone Replacement Therapy (Therapy, Hormone Replacement)
06/2012 - 02/2005
3Estrogen Replacement Therapy
06/2014 - 06/2003
1Intraperitoneal Injections
11/2017
1Drug Therapy (Chemotherapy)
07/2003